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Noxious mechanosensation - molecules and circuits.

Wood, JN; Eijkelkamp, N; (2012) Noxious mechanosensation - molecules and circuits. Current Opinion in Pharmacology , 12 (1) 4 - 8. 10.1016/j.coph.2011.10.013. Green open access

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Abstract

Drugs that block mechanically-evoked pain would be useful for many common pain conditions, but appropriate drug development targets have yet to be defined. There is increasing evidence that both peripheral sensory neuron wiring patterns as well as the expression of transducing molecules are important for modality specific pain sensations. Progress in identifying the cell types, candidate transducing molecules and wiring patterns involved in mechanosensation has been dramatic over the past few years. Here we focus on potential mechano-transducing channels, and the relevant cell types and wiring patterns that provide clues for new analgesic drug development strategies.

Type: Article
Title: Noxious mechanosensation - molecules and circuits.
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coph.2011.10.013
Publisher version: http://dx.doi.org/10.1016/j.coph.2011.10.013
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Analgesics, Animals, Drug Discovery, Gene Expression Regulation, Mechanotransduction, Cellular, Pain, Sensory Receptor Cells
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1347487
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