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Acute pain and a motivational pathway in adult rats: influence of early life pain experience.

Low, LA; Fitzgerald, M; (2012) Acute pain and a motivational pathway in adult rats: influence of early life pain experience. PLoS One , 7 (3) , Article e34316. 10.1371/journal.pone.0034316. Green open access

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Abstract

The importance of neonatal experience upon behaviour in later life is increasingly recognised. The overlap between pain and reward pathways led us to hypothesise that neonatal pain experience influences reward-related pathways and behaviours in adulthood.

Type: Article
Title: Acute pain and a motivational pathway in adult rats: influence of early life pain experience.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0034316
Publisher version: http://dx.doi.org/10.1371/journal.pone.0034316
Language: English
Additional information: © 2012 Low, Fitzgerald. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3314622 This work was funded by a London Pain Consortium 4-year PhD Studentship (LAL), which covered stipend, university fees, research costs and travel funds (http://www.lpc.ac.uk/html/index.php?data​id=309&pageid=51). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Acute Pain, Animals, Animals, Newborn, Behavior, Animal, Brain, Intracellular Signaling Peptides and Proteins, Male, Motivation, Neurons, Neuropeptides, Pain Threshold, Rats
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1346754
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