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Behavioral screening for neuroactive drugs in zebrafish

Rihel, J; Schier, AF; (2012) Behavioral screening for neuroactive drugs in zebrafish. Developmental Neurobiology , 72 (3) pp. 373-385. 10.1002/dneu.20910. Green open access

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Abstract

The larval zebrafish has emerged asa vertebrate model system amenable to small molecule screens for probing diverse biological pathways. Two large-scale small molecule screens examined the effects of thousands of drugs on larval zebrafish sleep/wake and photomotor response behaviors. Both screens identified hundreds of molecules that altered zebrafish behavior in distinct ways. The behavioral profiles induced by these small molecules enabled the clustering of compounds according to shared phenotypes. This approach identified regulators of sleep/wake behavior and revealed the biological targets for poorly characterized compounds. Behavioral screening for neuroactive small molecules in zebrafish is an attractive complement to in vitro screening efforts, because the complex interactions in the vertebrate brain can only be revealed in vivo.

Type: Article
Title: Behavioral screening for neuroactive drugs in zebrafish
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/dneu.20910
Publisher version: http://dx.doi.org/10.1002/dneu.20910
Language: English
Additional information: This is the peer reviewed version of the following article: Rihel, J; Schier, AF; (2012) Behavioral screening for neuroactive drugs in zebrafish. Developmental Neurobiology, 72 (3) pp. 373-385, which has been published in final form at http://dx.doi.org/10.1002/dneu.20910. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms).
Keywords: Animals, Behavior, Animal, Central Nervous System Stimulants, Drug Evaluation, Preclinical, Humans, Pharmaceutical Preparations, Sleep, Wakefulness, Zebrafish
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1345440
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