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Integrated dataset of screening hits against multiple neglected disease pathogens.

Nwaka, S; Besson, D; Ramirez, B; Maes, L; Matheeussen, A; Bickle, Q; Mansour, NR; ... Geary, T; + view all (2011) Integrated dataset of screening hits against multiple neglected disease pathogens. PLoS Negl Trop Dis , 5 (12) , Article e1412. 10.1371/journal.pntd.0001412. Green open access

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Abstract

New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. Our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative, multi-pathogen approach.

Type: Article
Title: Integrated dataset of screening hits against multiple neglected disease pathogens.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pntd.0001412
Publisher version: http://dx.doi.org/10.1371/journal.pntd.0001412
Language: English
Additional information: © 2011 Nwaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: Work produced was entirely supported by WHO public funds; no grants or external funding was used to maintain activities. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Antiparasitic Agents, Drug Discovery, Drug Evaluation, Preclinical, Humans, Neglected Diseases, Parasitic Diseases
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1337498
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