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Development of a model to aid NIRS data interpretation: results from a hypercapnia study in healthy adults

Moroz, T; Banaji, M; Tisdall, M; Cooper, CE; Elwell, CE; Tachtsidis, I; (2012) Development of a model to aid NIRS data interpretation: results from a hypercapnia study in healthy adults. In: Wolf, M and Bucher, HU and Rudin, M and Van Huffel, S and Wolf, U and Bruley, DF and Harrison, DK, (eds.) Oxygen Transport to Tissue XXXIII. (pp. 293 - 300). Springer Verlag: Berlin/ Heidelberg, Germany. Green open access

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Abstract

The use of a mathematical model of cerebral physiology and metabolism may aid the interpretation of experimentally measured data. In this study, model outputs of tissue oxygen saturation (TOS) and velocity of blood in the middle cerebral artery (Vmca) were compared with experimentally measured signals (TOS using near-infrared spectroscopy and Vmca using transcranial Doppler) acquired during hypercapnia in healthy volunteers. Initially, some systematic discrepancies between predicted and measured values of these variables were identified. The model was optimised to best fit the measured data by adjusting model parameters. To improve the fit, three additional model mechanisms were considered. These were: an extracerebral contribution to TOS, a change in venous volume with CO2 levels and a change in oxygen consumption with CO2 levels. Each mechanism, when used alone, improved the fit of the model to the data, although significant parameter changes were necessary. It is likely that a combination of these mechanisms will improve the success of modelling of TOS and Vmca changes during hypercapnia.

Type: Proceedings paper
Title: Development of a model to aid NIRS data interpretation: results from a hypercapnia study in healthy adults
Event: 38th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT)
Location: Ascona, Switzerland
Dates: 18 - 23 July, 2010
ISBN-13: 9781461415657
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4614-1566-4_43
Publisher version: http://dx.doi.org/10.1007/978-1-4614-1566-4_43
Language: English
Additional information: © 2012 Springer Verlag. The original publication is available at www.springerlink.com
Keywords: Adult, Blood Circulation, Brain, Carbon Dioxide, Data Interpretation, Statistical, Female, Humans, Hypercapnia, Male, Spectroscopy, Near-Infrared, Ultrasonography, Doppler, Transcranial
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1336362
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