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Use of a hybrid optical spectrometer for the measurement of changes in oxidized cytochrome c oxidase concentration and tissue scattering during functional activation

Ghosh, A; Tachtsidis, I; Kolyva, C; Cooper, CE; Smith, M; Elwell, CE; (2012) Use of a hybrid optical spectrometer for the measurement of changes in oxidized cytochrome c oxidase concentration and tissue scattering during functional activation. In: Wolf, M and Bucher, HU and Rudin, M and Van Huffel, S and Wolf, U and Bruley, DF and Harrison, DK, (eds.) Oxygen Transport to Tissue XXXIII. (119 - 124). Springer: New York, US. Green open access

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Abstract

We report the use of a novel dual-channel hybrid near-infrared optical spectrometer for the measurement of changes in oxidized cytochrome c oxidase (oxCCO) concentration and optical scattering in 11 healthy volunteers during functional activation induced by an anagram-solving task. A hemodynamic Changed ‘haemodynamic’ to ‘hemodynamic’ though followed UK spelling. Please check. response consistent with functional activation was seen in 9 out of 11 subjects and in 13 of the total 22 channels measured; only these channels were retained for further analysis. In each of these 13 channels the hemodynamic response was accompanied by a statistically significant change in [oxCCO], although the direction of this change was heterogenous with a significant increase seen in eight channels and a significant decrease seen in five channels. There was no significant change in the optical scattering coefficient measured at four wavelengths, and the use of differential pathlength factor (DPF) calculated in real-time using measured absorption and scattering showed a high level of agreement with a conventional algorithm. The possible reasons for the heterogeneity of the [oxCCO] response are discussed.

Type: Book chapter
Title: Use of a hybrid optical spectrometer for the measurement of changes in oxidized cytochrome c oxidase concentration and tissue scattering during functional activation
Location: United States
ISBN: 9781461415657
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4614-1566-4_18
Publisher version: http://dx.doi.org/10.1007/978-1-4614-1566-4_18
Language: English
Keywords: Adult, Brain, Electron Transport Complex IV, Female, Hemodynamics, Hemoglobins, Humans, Male, Oxidation-Reduction, Spectroscopy, Near-Infrared, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1336361
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