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Podocalyxin Is a Novel Polysialylated Neural Adhesion Protein with Multiple Roles in Neural Development and Synapse Formation

Vitureira, N; Andres, R; Perez-Martinez, E; Martinez, A; Bribian, A; Blasi, J; Chelliah, S; ... Soriano, E; + view all (2010) Podocalyxin Is a Novel Polysialylated Neural Adhesion Protein with Multiple Roles in Neural Development and Synapse Formation. PLOS ONE , 5 (8) , Article e12003. 10.1371/journal.pone.0012003. Green open access

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Abstract

Neural development and plasticity are regulated by neural adhesion proteins, including the polysialylated form of NCAM (PSA-NCAM). Podocalyxin (PC) is a renal PSA-containing protein that has been reported to function as an anti-adhesin in kidney podocytes. Here we show that PC is widely expressed in neurons during neural development. Neural PC interacts with the ERM protein family, and with NHERF1/2 and RhoA/G. Experiments in vitro and phenotypic analyses of podxl-deficient mice indicate that PC is involved in neurite growth, branching and axonal fasciculation, and that PC loss-offunction reduces the number of synapses in the CNS and in the neuromuscular system. We also show that whereas some of the brain PC functions require PSA, others depend on PC per se. Our results show that PC, the second highly sialylated neural adhesion protein, plays multiple roles in neural development.

Type: Article
Title: Podocalyxin Is a Novel Polysialylated Neural Adhesion Protein with Multiple Roles in Neural Development and Synapse Formation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0012003
Publisher version: http://dx.doi.org/10.1371/journal.pone.0012003
Language: English
Additional information: © 2010 Vitureira et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by grants from Ministerio de Ciencia e Innovación (BFU2008–3980) and La Caixa Foundation to ES, and the Comunidad de Castilla-La Mancha to FdeC, and FIS to FB. KMM is an MSFHR Scholar. This work was partially funded by a Canadian Institute for Heart Research grant and a Grant-in-Aid from the Heart and Stroke Foundation of BC and Yukon. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: LONG-TERM POTENTIATION, NEURONAL MIGRATION, MOUSE-BRAIN, IN-VIVO, ACTIN CYTOSKELETON, SIGNALING PATHWAYS, SEMAPHORIN 3A, MOLECULE NCAM, AXON GUIDANCE, MICE LACKING
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1332664
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