Morgan-Rowe, L;
Nikitorowicz, J;
Shiwen, X;
Leask, A;
Tsui, J;
Abraham, D;
Stratton, R;
(2011)
Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues.
Fibrogenesis Tissue Repair
, 4
, Article 13. 10.1186/1755-1536-4-13.
![[thumbnail of 1755-1536-4-13.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
1755-1536-4-13.pdf Download (942kB) |
Abstract
Systemic sclerosis (SSc) is a chronic inflammatory autoimmune disease characterised by vascular dysfunction and damage, excess collagen deposition and subsequent organ manifestations. Vasculopathy is an early feature of the disease which leads to a chronic hypoxic environment in the tissues. Paradoxically, there is a lack of angiogenesis. We hypothesised that this may in part be due to a nonphysiological, overriding upregulation in antiangiogenic factors produced by the hypoxic tissues. We considered thrombospondin 1 (TSP-1) as a candidate antiangiogenic factor.
Archive Staff Only
 |
View Item |
