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Axonal protein synthesis: a potential target for pain relief?

Obara, I; Géranton, SM; Hunt, SP; (2012) Axonal protein synthesis: a potential target for pain relief? Current Opinion in Pharmacology , 12 (1) 42 - 48. 10.1016/j.coph.2011.10.005. Green open access

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Abstract

Research on the role of axonal protein synthesis in the regulation of nociceptive mechanisms has grown significantly over the past four years. Recent advances include evidence that local translation of mRNA can occur in adult primary afferents under the control of the mammalian target of rapamycin (mTOR) and the extracellular signal-regulated kinase (ERK) signaling pathways. Studies investigating the effect of mTOR and ERK pathway inhibitors in a number of pain models suggest that these signaling pathways may act independently, depending on the type of sensory afferents studied. The evidence that nociception can be regulated at the level of mRNA translation in nociceptors has important implications for the understanding of the mechanisms of nociceptive plasticity and therefore for therapeutic interventions in chronic pain conditions.

Type: Article
Title: Axonal protein synthesis: a potential target for pain relief?
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coph.2011.10.005
Publisher version: http://dx.doi.org/10.1016/j.coph.2011.10.005
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Axons, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Humans, Nociceptors, Pain
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1329750
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