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Nasal Chemosensory-Stimulation Evoked Activity Patterns in the Rat Trigeminal Ganglion Visualized by In Vivo Voltage-Sensitive Dye Imaging

Rothermel, M; Ng, BSW; Grabska-Barwinska, A; Hatt, H; Jancke, D; (2011) Nasal Chemosensory-Stimulation Evoked Activity Patterns in the Rat Trigeminal Ganglion Visualized by In Vivo Voltage-Sensitive Dye Imaging. PLOS ONE , 6 (10) , Article e26158. 10.1371/journal.pone.0026158. Green open access

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Abstract

Mammalian nasal chemosensation is predominantly mediated by two independent neuronal pathways, the olfactory and the trigeminal system. Within the early olfactory system, spatiotemporal responses of the olfactory bulb to various odorants have been mapped in great detail. In contrast, far less is known about the representation of volatile chemical stimuli at an early stage in the trigeminal system, the trigeminal ganglion (TG), which contains neurons directly projecting to the nasal cavity. We have established an in vivo preparation that allows high-resolution imaging of neuronal population activity from a large region of the rat TG using voltage-sensitive dyes (VSDs). Application of different chemical stimuli to the nasal cavity elicited distinct, stimulus-category specific, spatiotemporal activation patterns that comprised activated as well as suppressed areas. Thus, our results provide the first direct insights into the spatial representation of nasal chemosensory information within the trigeminal ganglion imaged at high temporal resolution.

Type: Article
Title: Nasal Chemosensory-Stimulation Evoked Activity Patterns in the Rat Trigeminal Ganglion Visualized by In Vivo Voltage-Sensitive Dye Imaging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0026158
Publisher version: http://dx.doi.org/10.1371/journal.pone.0026158
Language: English
Additional information: © 2011 Rothermel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Deutsche Forschungsgemeinschaft: Collaborative Research Centre SFB 874 (Integration and Representation of Sensory Processes), Graduiertenkolleg 736 “Development and Plasticity of the Nervous System: Molecular, Synaptic and Cellular Mechanisms”, Ruhr-University Bochum, Germany [http://www.ruhr-uni-bochum.de/neuro-gk/] (MR, HH), Ruhr-University Research School funded by the DFG in the framework of the Excellence Initiative [http://www.research-school.rub.de/] (MR, BN, HH, DJ), DFG Neurovision SFB-509 [http://www.dfg.de/]); BMBF (Bundesministerium für Bildung und Forschung, start-up Junior Professorship, Bernstein Group for Computational Neuroscience) [http://www.bmbf.de/] (DJ), International Graduate School of Neuroscience (IGSN), Ruhr-University Bochum, Germany [http://www.ruhr-uni-bochum.de/igsn/index​.shtml] (BN, HH, DJ), Wilhelm und Günter Esser Stiftung, Ruhr-University Bochum, Germany [http://www.ruhr-uni-bochum.de/] (MR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: OLFACTORY-BULB, CAPSAICIN RECEPTOR, RESPONSES, DYNAMICS, NEURONS, CORTEX, SYSTEM, ORGANIZATION, ACTIVATION, CHANNELS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1329343
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