Boucrot, E;
Saffarian, S;
Zhang, R;
Kirchhausen, T;
(2010)
Roles of AP-2 in clathrin-mediated endocytosis.
PLOS One
, 5
(5)
, Article e10597. 10.1371/journal.pone.0010597.
![[thumbnail of 1322435.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
1322435.pdf Download (2MB) |
Abstract
The notion that AP-2 clathrin adaptor is an essential component of an endocytic clathrin coat appears to conflict with recent observations that substantial AP-2 depletion, using RNA interference with synthesis of AP-2 subunits, fails to block uptake of certain ligands known to internalize through a clathrin-based pathway.
| Type: | Article |
|---|---|
| Title: | Roles of AP-2 in clathrin-mediated endocytosis. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0010597 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0010597 |
| Language: | English |
| Additional information: | © 2010 Boucrot et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by National Institutes of Health (NIH) GM 075252 (T.K.), the International Human Frontier Science Program Organization (E.B.) and the American Heart Association (S.S.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | Adaptor Protein Complex 2, Clathrin, Coated Pits, Cell-Membrane, Endocytosis, HeLa Cells, Humans, Lipoproteins, LDL, RNA Interference, Surface Properties, Temperature, Transferrin |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1322435 |
Archive Staff Only
 |
View Item |
