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Roles of AP-2 in clathrin-mediated endocytosis.

Boucrot, E; Saffarian, S; Zhang, R; Kirchhausen, T; (2010) Roles of AP-2 in clathrin-mediated endocytosis. PLOS One , 5 (5) , Article e10597. 10.1371/journal.pone.0010597. Green open access

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Abstract

The notion that AP-2 clathrin adaptor is an essential component of an endocytic clathrin coat appears to conflict with recent observations that substantial AP-2 depletion, using RNA interference with synthesis of AP-2 subunits, fails to block uptake of certain ligands known to internalize through a clathrin-based pathway.

Type: Article
Title: Roles of AP-2 in clathrin-mediated endocytosis.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0010597
Publisher version: http://dx.doi.org/10.1371/journal.pone.0010597
Language: English
Additional information: © 2010 Boucrot et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by National Institutes of Health (NIH) GM 075252 (T.K.), the International Human Frontier Science Program Organization (E.B.) and the American Heart Association (S.S.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Adaptor Protein Complex 2, Clathrin, Coated Pits, Cell-Membrane, Endocytosis, HeLa Cells, Humans, Lipoproteins, LDL, RNA Interference, Surface Properties, Temperature, Transferrin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1322435
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