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The effect of biliary decompression on bacterial translocation in jaundiced rats

Ding, JW; Andersson, R; Soltesz, V; Willén, R; Loft, S; Poulsen, HE; Pärsson, H; ... Bengmark, S; + view all (1993) The effect of biliary decompression on bacterial translocation in jaundiced rats. HPB Surgery , 7 (2) 99 - 110. 10.1155/1993/69283. Green open access

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Abstract

Patients with obstructive jaundice are prone to septic complications after biliary tract operations. Restoring bile flow to the intestine may help to decrease the complication rate. The present study is aimed at evaluating the effect of biliary decompression on bacterial translocation in jaundiced rats. Sixty-six male Sprague-Dawley rats were randomly allocated to six groups subjected to common bile duct ligation (CBDL) and transection (groups 2-6) or sham operation (group 1). In groups 1 and 2 the incidence of enteric bacterial translocation was determined 2 weeks after sham operation or CBDL. In groups 3-6, biliary decompression was achieved by performing a choledochoduodenostomy after 2 weeks of biliary decompression. Bacterial translocation was then studied 1, 2, 3 and 5 weeks following biliary decompression. The rate of bacterial translocation to mesenteric lymph nodes in obstructive jaundice was significantly higher as compared with controls and decreased with time to nil three weeks following biliary decompression. The incidence of bacterial translocation was closely correlated (r = 0.844; p = 0.034) with serum alkaline phosphatase activity and seemed to fit with the morphological changes noted in the small intestine. The decrease in bacterial translocation, however, lags behind the recovery of liver function as measured by routine liver function tests and antipyrine clearance. Obstructive jaundice thus promotes bacterial translocation in the rat. Biliary decompression gradually decreases the rate of bacterial translocation.

Type: Article
Title: The effect of biliary decompression on bacterial translocation in jaundiced rats
Location: SWITZERLAND
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/1993/69283
Publisher version: http://dx.doi.org/10.1155/1993/69283
Language: English
Additional information: Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Animals, Bacteria, Bacterial Physiological Phenomena, Cell Movement, Choledochostomy, Cholestasis, Epithelium, Intestine, Small, Liver Function Tests, Lymph Nodes, Male, Mesentery, Random Allocation, Rats, Rats, Sprague-Dawley
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1313684
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