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Reticuloendothelial System Function Following Acute Liver Failure Induced by 90% Hepatectomy in the Rat

Wang, X; Andersson, R; Ding, J; Norgren, L; Bengmark, S; (1993) Reticuloendothelial System Function Following Acute Liver Failure Induced by 90% Hepatectomy in the Rat. HPB Surgery , 6 (3) 151 - 162. 10.1155/1993/27630. Green open access

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Abstract

Sepsis and bacterial infections are frequent complications of acute liver failure and following major liver resection. The mechanisms underlying this phenomenon are unclear. In this study, RES function and blood clearance of radiolabelled E. coli was immediately impaired following 90% hepatectomy, although the reduction in liver volume resulted in an increase in splenic (temporary) and pulmonary (persisting) uptake. A significant correlation between liver function and host RES function was observed. The uptake capacity of the RES in the liver remnant and spleen did not correlate with subserosal blood flow. The uptake in the brain gradually increased with time, paralleling an increased leakage across the blood-brain barrier. Thus, a significantly impaired RES function resulted from experimental 90% hepatectomy-induced acute liver failure, which might explain the high incidence of septic events in the clinical situation.

Type: Article
Title: Reticuloendothelial System Function Following Acute Liver Failure Induced by 90% Hepatectomy in the Rat
Location: SWITZERLAND
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/1993/27630
Publisher version: http://dx.doi.org/10.1155/1993/27630
Language: English
Additional information: Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Animals, Bacteremia, Escherichia coli, Escherichia coli Infections, Hepatectomy, Iodine Radioisotopes, Kidney, Liver, Liver Circulation, Liver Failure, Acute, Liver Function Tests, Lung, Male, Mononuclear Phagocyte System, Rats, Rats, Sprague-Dawley, Regional Blood Flow, Spleen, Survival Rate, Time Factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1313453
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