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Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

Freathy, RM; Kazeem, GR; Morris, RW; Johnson, PC; Paternoster, L; Ebrahim, S; Hattersley, AT; ... Munafò, M; + view all (2011) Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology , 40 (6) pp. 1617-1628. 10.1093/ije/dyr077. Green open access

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Abstract

Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.

Type: Article
Title: Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/ije/dyr077
Publisher version: http://dx.doi.org/10.1093/ije/dyr077
Language: English
Additional information: Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2011; all rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adult, Aged, Body Composition, Body Mass Index, Clinical Trials as Topic, Female, Genotype, Humans, Male, Middle Aged, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Receptors, Nicotinic, Smoking, Weight Gain
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1307757
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