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Improving lipid profiles and increasing use of lipid-lowering therapy in England: results from a national cross-sectional survey-2006

Mindell, J; Aresu, M; Zaninotto, P; Falaschetti, E; Poulter, N; (2011) Improving lipid profiles and increasing use of lipid-lowering therapy in England: results from a national cross-sectional survey-2006. Clinical Endocrinology , 75 (5) 621 - 627. 10.1111/j.1365-2265.2011.04094.x. Green open access

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Abstract

Objective To evaluate blood lipid levels in the adult English population in 2006 and to report change in the use and efficacy of lipid-lowering treatment since 2003 after which time the general practitioner contract introduced a 'pay-per-performance' approach.Design Cross-sectional surveys.Participants Nationally representative sample of 14 142 noninstitutionalized adults (>16 years) living in England, partaking in the Health Survey for England 2006.Measurements Mean levels of total, HDL, non-HDL and total/HDL cholesterol ratio, prevalence of hypercholesterolaemia, use of lipid lowering agents and lipid levels and control rates among those on treatment.Results Age-standardized mean cholesterol levels fell from 5.49 mm in men and 5.56 mm in women in 2003 to 5.26 and 5.37 mm, respectively, in 2006. In 2006, 59% of adults had a total cholesterol >= 5.0 mm and 11% reported lipid-lowering treatment, of whom 66% had a total cholesterol <5.0 mm and 22% were <4.0 mm. The majority of those with established coronary heart disease, stroke or diabetes but fewer than one quarter of those with hypertension or 20% estimated 10-year cardiovascular risk and no established CVD took lipid-lowering drugs. Lipid lowering treatment rates increased fivefold and control rates among the treated (to <5.0 mm) more than doubled between 1998 and 2006. About one-third of those with established CVD or diabetes had cholesterol levels of <4.0 mm.Conclusions Previously reported improvements in treatment and control rates between 1998 and 2003 continued between 2003 and 2006, with the biggest increases among those with established CVD and diabetes.

Type: Article
Title: Improving lipid profiles and increasing use of lipid-lowering therapy in England: results from a national cross-sectional survey-2006
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/j.1365-2265.2011.04094.x
Publisher version: http://dx.doi.org/10.1111/j.1365-2265.2011.04094.x
Language: English
Additional information: © 2011 Blackwell Publishing Ltd. This is the pre-peer reviewed version of the following article: Clinical Endocrinology (2011) 75, 621–627, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2011.04094.x/abstract
Keywords: CORONARY-HEART-DISEASE, CARDIOVASCULAR-DISEASE, HEALTH SURVEY, RISK-FACTORS, GUIDELINES, MANAGEMENT, HYPERTENSION, IMPROVEMENT, PREVENTION, MORTALITY
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/1307732
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