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Hyper-IgG4 disease: report and characterisation of a new disease

Neild, GH; Rodriguez-Justo, M; Wall, C; Connolly, JO; (2006) Hyper-IgG4 disease: report and characterisation of a new disease. BMC Medicine , 4 , Article 23. 10.1186/1741-7015-4-23. Green open access

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Abstract

We highlight a chronic inflammatory disease we call 'hyper-IgG4 disease', which has many synonyms depending on the organ involved, the country of origin and the year of the report. It is characterized histologically by a lymphoplasmacytic inflammation with IgG4-positive cells and exuberant fibrosis, which leaves dense fibrosis on resolution. A typical example is idiopathic retroperitoneal fibrosis, but the initial report in 2001 was of sclerosing pancreatitis.

Type: Article
Title: Hyper-IgG4 disease: report and characterisation of a new disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1741-7015-4-23
Publisher version: http://dx.doi.org/10.1186/1741-7015-4-23
Language: English
Additional information: PMCID: PMC1618394 © 2006 Neild et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons. org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the orig inal work is properly cited.
Keywords: Adult, Diagnosis, Differential, Diagnostic Errors, Humans, Hypergammaglobulinemia, Immunoglobulin G, Male, Plasma Cells, Retroperitoneal Fibrosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1307283
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