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Memory modulation by offline consolidation and transcranial direct current stimulation

Javadi Arjomand, A.H.; (2011) Memory modulation by offline consolidation and transcranial direct current stimulation. Doctoral thesis , UCL (University College London). Green open access

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Two groups of experiments are discussed in this thesis, (a) procedural memory consolidation during sleep and wakefulness, to study the contribution of emotion in consolidation of procedural skill learning, and (b) memory modulation using electrical brain stimulation, to study the effects of long‐ and short‐duration stimulation of left dorsolateral prefrontal cortex (DLPFC) on verbal episodic memory. Memory consolidation; The first study showed that participants who were trained in a mirror tracing task with negative emotional stimuli benefited more compared to the participants who were trained with neutral or positive emotional stimuli. The second experiment aimed to investigate the modulatory effect of stimuli with emotional content in a modified serial reaction time task (SRTT). This experiment failed to achieve any main effect of emotional content, retention type, their interaction or their interaction with session number. The only significant effect was found for the session number in which participants showed significantly higher performance in the second session. It is more likely that this outcome is due to the training effects over blocks. Brain stimulation; The first study showed that 20min anodal stimulation enhanced memory performance while the stimulation was delivered during the encoding phase, 20min cathodal stimulation impaired memory performance for the words that were encoded prior to the stimulation and impaired the recognition performance while it was delivered during the testing phase. The second study was similar to the first experiment with the exception that stimulation was delivered for 1.6s for each presented word in three different conditions: no stimulation, early‐stimulation and late‐stimulation. Results showed that early stimulation has significantly stronger effects on the memory performance of the participants compared to nostimulation and late‐stimulation in both anodal and cathodal stimulation types. Results also showed that early anodal stimulation enhanced the memory performance and early cathodal stimulation impaired the memory performance.

Type: Thesis (Doctoral)
Title: Memory modulation by offline consolidation and transcranial direct current stimulation
Open access status: An open access version is available from UCL Discovery
Language: English
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1306720
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