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Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease.

Shamaei-Tousi, A; D'Aiuto, F; Nibali, L; Steptoe, A; Coates, AR; Parkar, M; Donos, N; (2007) Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease. PLoS One , 2 (11) , Article e1198. 10.1371/journal.pone.0001198. Green open access

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Abstract

Evidence is emerging that molecular chaperones, in addition to their intracellular protein folding actions, can act as intercellular signaling proteins with an ability to modulate leukocyte function. Recent evidence has also shown that these proteins can exist in the circulation and may be involved in disease pathogenesis. We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP.

Type: Article
Title: Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0001198
Publisher version: http://dx.doi.org/10.1371/journal.pone.0001198
Language: English
Additional information: PMCID: PMC2065903 © 2007 Shamaei-Tousi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. We are grateful to the British Heart Foundation (grant PG/03/029) for support to BH, AS, ARMC and for financial support for AS-T.
Keywords: Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Molecular Chaperones, Periodontitis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: https://discovery.ucl.ac.uk/id/eprint/116871
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