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The relationship between HIV seroconversion illness, HIV test interval and time to AIDS in a seroconverter cohort.

Tyrer, F; Walker, AS; Gillett, J; Porter, K; UK Register of HIV Seroconverters, UK; (2003) The relationship between HIV seroconversion illness, HIV test interval and time to AIDS in a seroconverter cohort. Epidemiol Infect , 131 (3) 1117 - 1123. 10.1017/S0950268803001377. Green open access

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Abstract

Seroconversion illness is known to be associated with more rapid HIV disease progression. However, symptoms are often subjective and prone to recall bias. We describe symptoms reported as seroconversion illness and examine the relationship between illness, HIV test interval (time between antibody-negative and anibody-positive test dates) and the effect of both on time to AIDS from seroconversion. We used a Cox model, adjusting for age, sex, exposure group and year of estimated seroconversion. Of 1820 individuals, information on seroconversion illness was available for 1244 of whom 423 (34%) reported symptomatic seroconversion. Persons with a short test interval (< or = 2 months) were significantly more likely to report an illness than people with a longer interval (OR 6.76, 95% CI 4.75-9.62). Time to AIDS was significantly faster (P = 0.01) in those with a short test interval. The HIV test interval is a useful replacement for information on seroconversion illness in studies of HIV disease progression.

Type: Article
Title: The relationship between HIV seroconversion illness, HIV test interval and time to AIDS in a seroconverter cohort.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0950268803001377
Publisher version: http://dx.doi.org/10.1017/S0950268803001377
Language: English
Additional information: PMCID: PMC2870061 © 2003 Cambridge University Press
Keywords: Acquired Immunodeficiency Syndrome, Adolescent, Adult, Aged, Antibodies, Viral, Cohort Studies, Disease Progression, Female, HIV, HIV Seropositivity, Humans, Male, Middle Aged, Models, Theoretical, Serologic Tests, Time Factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/110152
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