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Spatial genetic Patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex

Fogarty, M; Grist, M; Gelman, D; Marin, O; Pachnis, V; Kessaris, N; (2007) Spatial genetic Patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex. J NEUROSCI , 27 (41) 10935 - 10946. 10.1523/JNEUROSCI.1629-07.2007. Green open access

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Abstract

Cortical pyramidal cells are generated from pallial neuroepithelial precursors, whereas GABAergic interneurons originate in subpallial germinal zones and migrate tangentially to reach the cortex. Using Cre-lox technology in transgenic mice and a series of molecular markers that subdivide the subpallial neuroepithelium into small domains, we fate-map precursor pools and identify interneurons generated from each domain. Cortical interneurons expressing calbindin, parvalbumin, and somatostatin are generated exclusively from Lhx6 (Lim homeobox 6)-expressing precursors in the medial ganglionic eminence (MGE). Martinotti cells that coexpress calretinin and somatostatin are generated from the dorsal region of the MGE neuroepithelium that expresses Nkx6.2 (NK2 transcription factor-related 6.2). Most neuropeptide Y-expressing cells and all bipolar calretinin-expressing interneurons are generated outside the MGE, from the germinal zones of the lateral/caudal ganglionic eminences that express Gsh2 ( genomic screened homeobox 2). Our data demonstrate that subpallial neuroepithelial domains defined by expression of genetic determinants generate distinct interneuron subtypes, thereby contributing to the generation of cortical interneuron heterogeneity observed in the adult cortex.

Type: Article
Title: Spatial genetic Patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.1629-07.2007
Keywords: cell fate, cortex, Cre-transgenic, development, GABAergic neuron, interneurons, DECARBOXYLASE IMMUNOREACTIVE CELLS, CAUDAL GANGLIONIC EMINENCE, CORTICAL INTERNEURONS, CEREBRAL-CORTEX, BASAL FOREBRAIN, SONIC HEDGEHOG, IN-VITRO, NEURONS, MOUSE, MIGRATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10787
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