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Setting Research Priorities to Reduce Almost One Million Deaths from Birth Asphyxia by 2015

Lawn, JE; Bahl, R; Bergstrom, S; Bhutta, ZA; Darmstadt, GL; Ellis, M; English, M; ... Rudan, I; + view all (2011) Setting Research Priorities to Reduce Almost One Million Deaths from Birth Asphyxia by 2015. PLoS Medicine , 8 (1) , Article e1000389. 10.1371/journal.pmed.1000389. Green open access

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Abstract

Intrapartum-related neonatal deaths (previously called “birth asphyxia”) are the fifth most common cause of deaths among children under 5 years of age, accounting for an estimated 814,000 deaths each year, and also associated with significant morbidity, resulting in a burden of 42 million disability adjusted life years (DALYs). This paper uses a systematic process developed by the Child Health Nutrition Research Initiative (CHNRI) to define and rank research options to reduce mortality from intrapartum-related neonatal deaths by the year 2015, in order to advance Millennium Development Goal (MDG) 4 for child survival. A list of 61 research questions was developed and scored by 21 technical experts. The top one-third of the ranked research investment options was dominated by delivery (implementation) research, whilst discovery (basic science) questions were not ranked highly, especially for expected reduction of mortality and inequity in the short time to 2015. Among the top four research questions, two relate to generation of demand for facility care at birth with specific mechanisms (such as transport and communication schemes, or financial incentives and conditional cash transfers). The other two top ranked priorities relate to use of community cadres and the roles they might effectively play—for example, screening for complications or supportive transfer to facilities and companionship at birth. The highest ranked discovery question concerned the interaction of hypoxia and infection, and the highest ranked epidemiologic question addressed prediction of intrapartum hypoxic injury. This exercise highlights the need for current research investments to focus on studies most likely to result in accelerated progress towards MDG 4 and in the countries where the most deaths occur.

Type: Article
Title: Setting Research Priorities to Reduce Almost One Million Deaths from Birth Asphyxia by 2015
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pmed.1000389
Publisher version: http://dx.doi.org/10.1371/journal.pmed.1000389
Language: English
Additional information: © 2011 Lawn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: HEALTH RESEARCH INVESTMENTS, LOW-RESOURCE SETTINGS, INTRAPARTUM-RELATED DEATHS, MILLENNIUM DEVELOPMENT GOAL, CHILD HEALTH, NEONATAL DEATHS, OVERCOME CHALLENGES, SYSTEMATIC ANALYSIS, NEWBORN SURVIVAL, GLOBAL HEALTH
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
URI: https://discovery.ucl.ac.uk/id/eprint/1058190
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