UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Grading objective diagnostic components in paroxysmal events: One-year follow-up at a tertiary epilepsy center

Aaftink, Daniel; Reijneveld, Jaap C; De Lange, Frederik; Sander, Josemir W; Thijs, Roland D; (2024) Grading objective diagnostic components in paroxysmal events: One-year follow-up at a tertiary epilepsy center. Epilepsia , 65 (9) pp. 2700-2708. 10.1111/epi.18062.

[thumbnail of SCOPE_revisedmanuscript_final.pdf] Text
SCOPE_revisedmanuscript_final.pdf - Accepted Version
Access restricted to UCL open access staff until 27 July 2025.

Download (1MB)

Abstract

Objective: This study was undertaken to develop a model and perform a preliminary internal validation study of the Scale for Objective Diagnostic Components of Paroxysmal Events (STAMP). // Methods: We developed STAMP, which builds on the International League Against Epilepsy task force scale for functional seizures with additional categories for epileptic seizures and syncope. We included 200 consecutive referrals to a Dutch tertiary epilepsy center to evaluate seizurelike events. We recorded demographic and clinical data and collected the clinical evaluation at referral and after 3, 6, 9, and 12 months of follow-up. We ascertained the STAMP at each time point and evaluated factors predicting an improvement in STAMP grade during follow-up. // Results: Of the 200 referrals at baseline, 131 were classified as having epileptic seizures, 17 as functional seizures, and three as syncope, and 49 were unclassifiable. STAMP grade at baseline was 4 (absent) in 56 individuals, 3 (circumstantial) in 78, 2 (clinically established) in six, and 1 (documented) in 11. Over time, 62 cases STAMP grades improved, and 23 remained unclassifiable. A refinement of STAMP grade during follow-up was due to successful event recordings in 34 people (30 video-electroencephalographic [EEG] recordings, four tilt table testing), home videos or clinician-witnessed events in 13, and identification of interictal EEG or magnetic resonance imaging abnormalities in seven. An improved STAMP grade after 12 months of follow-up was significantly more likely in those with higher event frequency, unclassifiable events, longer event duration, and a shorter time since the first event and less likely in those with a history suggestive of seizures. // Significance: This epilepsy service evaluation underscores the crucial role of event recording in improving diagnostic certainty. STAMP may be used to monitor diagnostic performance over time but requires further validation.

Type: Article
Title: Grading objective diagnostic components in paroxysmal events: One-year follow-up at a tertiary epilepsy center
Location: United States
DOI: 10.1111/epi.18062
Publisher version: http://dx.doi.org/10.1111/epi.18062
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Certainty; classification; diagnosis; functional seizures; syncope
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10197830
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item