Chen, Feifan;
Fahimi Hnazaee, Mansoureh;
Vanneste, Sven;
Mohan, Anusha;
(2024)
Effective Connectivity Network of Aberrant Prediction Error Processing in Auditory Phantom Perception.
Brain Connectivity
10.1089/brain.2024.0013.
(In press).
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Abstract
Prediction error (PE) is key to perception in the predictive coding framework. However, previous studies indicated the varied neural activities evoked by PE in tinnitus patients. Here, we aimed to reconcile the conflict by 1) a more nuanced view of PE, which could be driven by changing of stimulus (stimulus-driven prediction error, sPE) and violation of current context (context-driven prediction error, cPE) and 2) investigating the aberrant connectivity networks that are engaged in the processing of the two types of PEs in tinnitus patients. Ten tinnitus patients with normal hearing and healthy controls were recruited and a local-global auditory oddball paradigm was applied to measure the electroencephalographic difference between the two groups during sPE and cPE conditions. Overall, the sPE condition engaged bottom-up and top-down connections, whereas the cPE condition engaged mostly top-down connections. The tinnitus group showed decreased sensitivity to the sPE and increased sensitivity to the cPE condition. Particularly, the auditory cortex and posterior cingulate cortex were the hubs for processing cPE in the control and tinnitus groups respectively showing the orientation to an internal state in tinnitus. Furthermore, tinnitus patients showed stronger connectivity to the parahippocampus and pregenual anterior cingulate cortex for the establishment of the prediction during the cPE condition. These results begin to dissect the role of changes in stimulus characteristics vs changes in the context of processing the same stimulus in mechanisms of tinnitus generation.
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