Van't Wout, E;
Haqshenas, R;
Gelat, P;
(2024)
Simulating Focused Ultrasound with the Boundary Element Method.
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2024 IEEE UFFC Latin America Ultrasonics Symposium, LAUS 2024 - Proceedings.
IEEE
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Abstract
Focused ultrasound is a non-invasive, non-ionizing technology with great potential for various clinical applications, including thermal ablation of tumors, targeted drug delivery, and neuromodulation. Focused ultrasound uses ultrasound energy to treat tissue deep in the body. Optimizing treatment parameters to achieve desired clinical outcomes while minimizing adverse effects remains a significant challenge. Computational simulations are powerful tools to address this challenge, develop patient-specific treatment plans and general safety guidelines, and optimize ultrasound transducers. This study presents the development of an open-source Python library, named OptimUS, for calculating ultrasound wave propagation in large computational domains in 3D using the boundary element method, specifically for focused ultrasound applications. The numerical calculations only require surface meshes at the scatterers' interfaces to define the model's geometry. Also, the computations are fast and accurate for high-frequency waves through materials with high contrast in density and speed of sound. An intercomparison exercise supports the fidelity of the simulations. Finally, simulations using anatomical models for abdominal applications of focused ultrasound reliably show the aberration of the focus from reflections by ribs and the presence of prefocal hotspots due to the lensing effect of fat layers.
| Type: | Proceedings paper |
|---|---|
| Title: | Simulating Focused Ultrasound with the Boundary Element Method |
| Event: | 2024 IEEE UFFC Latin America Ultrasonics Symposium (LAUS) |
| Location: | URUGUAY, Montevideo |
| Dates: | 8 May 2024 - 10 May 2024 |
| ISBN-13: | 979-8-3503-4909-2 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/LAUS60931.2024.10553133 |
| Publisher version: | https://doi.org/10.1109/LAUS60931.2024.10553133 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Ultrasonics, computational acoustics, biomedical engineering, boundary element method |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10195934 |
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