Smith, EMD;
Aggarwal, A;
Ainsworth, J;
Al-Abadi, E;
Avcin, T;
Bortey, L;
Burnham, J;
... Marks, SD; + view all
(2024)
Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force.
Clinical Immunology
, 263
, Article 110214. 10.1016/j.clim.2024.110214.
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Abstract
Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. // Methods: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. // Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. // Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.
| Type: | Article |
|---|---|
| Title: | Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clim.2024.110214 |
| Publisher version: | http://dx.doi.org/10.1016/j.clim.2024.110214 |
| Language: | English |
| Additional information: | Copyright © 2024 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Treat-to-target; T2T; Childhood-onset SLE; cSLE; Remission |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10190819 |
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