UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Progress is impossible without change: understanding the evolving nomenclature of steatotic liver disease and its effect on hepatology practice

Brennan, Paul N; Tavabie, Oliver D; Li, Wenhao; Marjot, Thomas; Corless, Lynsey; Fallowfield, Jonathan A; Jarvis, Helen; ... Abeysekera, Kushala WM; + view all (2024) Progress is impossible without change: understanding the evolving nomenclature of steatotic liver disease and its effect on hepatology practice. The Lancet Gastroenterology & Hepatology , 9 (6) pp. 577-582. 10.1016/S2468-1253(23)00453-3. Green open access

[thumbnail of Tsochatzis_LGH_SLD Viewpoint_Revis2_clean.pdf]
Preview
Text
Tsochatzis_LGH_SLD Viewpoint_Revis2_clean.pdf

Download (369kB) | Preview

Abstract

The American, European, and Latin American liver societies have proposed a change in the nomenclature we use to describe alcohol-related liver disease and non-alcoholic fatty liver disease. Additionally, a term encompassing both is now advocated: steatotic liver disease, which includes metabolic dysfunction associated steatotic liver disease (MASLD) and MASLD with greater alcohol consumption (MetALD). These classifications offer increased relevance for clinicians, researchers, and patients alike. In this Viewpoint, we discuss the basis for this nomenclature shift and how it was developed. We also explore the challenges that will be faced in the adoption of such change. The proposed change seeks to banish stigma associated with phrasing such as alcoholic and fatty. However stigma, particularly related to the term fatty, is culturally nuanced, and reflects different entities depending on location. If such a change is internationally accepted, there will be wide-reaching effects on practitioners in primary care and metabolic medicine, and on patients. We discuss those effects and the opportunities the nomenclature change could offer, particularly for patients with alcohol and metabolic risk factors who represent a group previously ignored by clinical trials.

Type: Article
Title: Progress is impossible without change: understanding the evolving nomenclature of steatotic liver disease and its effect on hepatology practice
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S2468-1253(23)00453-3
Publisher version: http://dx.doi.org/10.1016/s2468-1253(23)00453-3
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10190560
Downloads since deposit
4Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item