Walsh, Sebastian;
Wallace, Lindsay;
Kuhn, Isla;
Mytton, Oliver;
Lafortune, Louise;
Wills, Wendy;
Mukadam, Naaheed;
(2024)
Population-level interventions for the primary prevention of dementia: a complex evidence review.
eClinicalMedicine
, 70
, Article 102538. 10.1016/j.eclinm.2024.102538.
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Abstract
Dementia risk reduction is a global public health priority. Existing primary prevention approaches have favored individual-level interventions, with a research and policy gap for population-level interventions. We conducted a complex, multi-stage, evidence review to identify empirical evidence on population-level interventions for each of the modifiable risk factors identified by the Lancet Commission on dementia (2020). Through a comprehensive series of targeted searches, we identified 4604 articles, of which 135 met our inclusion criteria. We synthesized evidence from multiple sources, including existing non-communicable disease prevention frameworks, and graded the consistency and comprehensiveness of evidence. We derived a population-level intervention framework for dementia risk reduction, containing 26 high- and moderate-confidence policy recommendations, supported by relevant information on effect sizes, sources of evidence, contextual information, and implementation guidance. This review provides policymakers with the evidence they need, in a useable format, to address this critical public health policy gap.
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