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Revolutionizing drug delivery by bioinspired 4D transdermal microneedles: Advances and future horizons

Raikar, Amisha S; Kalaskar, Deepak; Bhilegaonkar, Shilpa; Somnache, Sandesh N; Bodaghi, Mahdi; (2024) Revolutionizing drug delivery by bioinspired 4D transdermal microneedles: Advances and future horizons. European Polymer Journal , 210 , Article 112952. 10.1016/j.eurpolymj.2024.112952. (In press). Green open access

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Abstract

Transdermal drug delivery holds great promise for enhancing therapeutic outcomes and patient compliance, and bioinspired 4D microneedles represent a cutting-edge approach in this field. This review provides a concise overview on the current progress and future prospects in the development of bioinspired 4D transdermal microneedles for drug delivery. Bioinspired 4D microneedles combine the principles of biomimicry and advanced materials science to create dynamic, responsive drug delivery systems. They are designed to overcome the limitations of conventional transdermal patches by offering enhanced control over drug release, improved patient comfort, and the ability to adapt to the dynamic properties of the skin. In this article, we discuss various fabrication techniques, materials, and designs are discussed that have been explored to create these innovative microneedles. This article explores various fabrication techniques, materials and designs of innovative microneedles. Current research in this field has demonstrated that bioinspired 4D microneedles enables precise and controlled drug administration for a wide range of therapeutic applications. These microneedles have shown potential in delivering both small molecule drugs and biologics, making them versatile tools in the pharmaceutical industry. Ongoing research efforts focus on improving biocompatibility, scalability, and commercial viability. The integration with smart technologies such as sensors and feedback control systems enable personalized and responsive delivery of drug. Bioinspired 4D transdermal microneedles represent a transformative approach to drug delivery. They offer precise, patient-friendly, and adaptable solutions for delivering a wide range of therapeutics. With continued research and development, Bioinspired 4D microneedles have the potential to revolutionize the way of drug administration, ultimately improving healthcare of the patient.

Type: Article
Title: Revolutionizing drug delivery by bioinspired 4D transdermal microneedles: Advances and future horizons
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.eurpolymj.2024.112952
Publisher version: http://dx.doi.org/10.1016/j.eurpolymj.2024.112952
Language: English
Additional information: © 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Transdermal drug delivery, Bioinspired microneedles, 4D Microneedles, Biomimicry, 4D Printing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10189415
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