Venturelli, Veronica;
Abrantes, Ana Mafalda;
Rahman, Anisur;
Isenberg, David A;
(2024)
The impact of antiphospholipid antibodies/antiphospholipid syndrome on systemic lupus erythematosus.
Rheumatology
, 63
(SI)
SI72-SI85.
10.1093/rheumatology/kead618.
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Abstract
aPLs are a major determinant of the increased cardiovascular risk in patients with SLE. They adversely affect clinical manifestations, damage accrual and prognosis. Apart from the antibodies included in the 2006 revised classification criteria for APS, other non-classical aPLs might help in identifying SLE patients at increased risk of thrombotic events. The best studied are IgA anti-β2-glycoprotein I, anti-domain I β2-glycoprotein I and aPS-PT. Major organ involvement includes kidney and neuropsychiatric systems. aPL/APS severely impacts pregnancy outcomes. Due to increased thrombotic risk, these patients require aggressive cardiovascular risk factor control. Primary prophylaxis is based on low-dose aspirin in high-risk patients. Warfarin is the gold-standard drug for secondary prophylaxis.
| Type: | Article |
|---|---|
| Title: | The impact of antiphospholipid antibodies/antiphospholipid syndrome on systemic lupus erythematosus |
| Location: | England |
| DOI: | 10.1093/rheumatology/kead618 |
| Publisher version: | http://dx.doi.org/10.1093/rheumatology/kead618 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Antiphospholipid antibodies, antiphospholipid syndrome, clinical outcomes, management, prognosis, systemic lupus erythematosus |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10188448 |
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