Hong, J;
Zhu, J;
Cao, X;
Pang, B;
Xian, J;
Yin, X;
Deng, Q;
... Li, M; + view all
(2024)
Photo-triggered multifunctional gold-based hybrid nanoflowers promote infectious skin regeneration.
Chemical Engineering Journal
, 482
, Article 148937. 10.1016/j.cej.2024.148937.
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Abstract
The skin wound-healing under infectious conditions remains challenging owing to the lack of efficient strategies to inhibit drug-resistant bacteria growth and control inflammation. Photothermal therapy shows efficient antimicrobial effects, whereas it generates excessive heat to damage tissue and inflammation to impair tissue regeneration. Herein, we develop the multifunctional gold-based nanoflowers incorporated with photosensitizer (Ce6, for PDT) and anti-inflammatory drug (bromfenac sodium/BS). This allows for a nanosystem to combine the mild-photothermal therapy (mPTT), photodynamic therapy (PDT), and drug-controlled release anti-inflammation therapy for infectious skin regeneration. Upon laser irradiation, the local temperature increased (to a mild temperature of ∼ 45 ℃, mPTT) along with the singly linear oxygen (from PDT) for anti-infection; the release of BS was triggered for anti-inflammation. The multifunctional nanoflowers achieved 99 % antibacterial efficiencies and biofilm inhibition in vitro. They showed good biocompatibility and improved wound-healing in the animal models of subcutaneous abscess and skin wound infected with drug-resistant bacteria. In addition to the antibacterial effect from mPTT and PDT, the nanoflowers regulated the immune microenvironment by controlled releasing BS, inhibiting inflammation and promoting growth factor production, collagen deposition, and angiogenesis to improve skin wound-healing. Therefore, this study provides an advanced nano-system with photo-triggered antimicrobial and anti-inflammation activities, which improves infectious skin tissue regeneration.
| Type: | Article |
|---|---|
| Title: | Photo-triggered multifunctional gold-based hybrid nanoflowers promote infectious skin regeneration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cej.2024.148937 |
| Publisher version: | https://doi.org/10.1016/j.cej.2024.148937 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Mild photothermal antibacterial therapy, Gold-based hybrid nanoflowers, Photo-triggered drug release, Anti-inflammation, Infectious skin tissue regeneration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10187511 |
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