Sawadkar, Prasad; Lali, Ferdinand; Jayasinghe, Suwan N; (2024) Bio-jetted human adipose-derived stem cells remain viable. Next Materials , 2 , Article 100108. 10.1016/j.nxmate.2024.100108.

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Abstract

Direct cell handling processes are increasingly becoming important as they allow the controlled deposition of living cells, with precision for a vast number of applications, spanning the printing of cells in either 2D/3D for the reconstruction of fully functional tissues to the delivery of therapeutic architectures bearing cells and genes of interest. Architectures reconstructed with such cells etc are most useful as models, for studying a wide range of molecular and cellular behaviours, to the development of personalised medicines. Our previous work demonstrated the ability for aerodynamically assisted bio-jets to process single and multiple cell-bearing suspensions, to whole fertilised embryos. Those studies found that the post-treated cells and embryos were indistinguishable from untreated controls. In the present study the authors further validate this jetting technology for the direct handling of stem cells, by demonstrating their viability post-treatment and their capacity to differentiate in comparison to controls. These studies together with our previous work unveil, aerodynamically assisted bio-jets as a platform biotechnology for the direct handling of a wide range of cells and embryos.

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