de Oliveira, Diana C;
Espino, Daniel M;
Deorsola, Luca;
Buchan, Keith;
Dawson, Dana;
Shepherd, Duncan ET;
(2023)
A geometry-based finite element tool for evaluating mitral valve biomechanics.
Medical Engineering and Physics
, 121
, Article 104067. 10.1016/j.medengphy.2023.104067.
![[thumbnail of Cruz De Oliveira_Manuscript revised - clean version.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
Cruz De Oliveira_Manuscript revised - clean version.pdf Access restricted to UCL open access staff until 1 November 2024. Download (1MB) |
Abstract
Mitral valve function depends on its complex geometry and tissue health, with alterations in shape and tissue response affecting the long-term restorarion of function. Previous computational frameworks for biomechanical assessment are mostly based on patient-specific geometries; however, these are not flexible enough to yield a variety of models and assess mitral closure for individually tuned morphological parameters or material property representations. This study details the finite element approach implemented in our previously developed toolbox to assess mitral valve biomechanics and showcases its flexibility through the generation and biomechanical evaluation of different models. A healthy valve geometry was generated and its computational predictions for biomechanics validated against data in the literature. Moreover, two mitral valve models including geometric alterations associated with disease were generated and analysed. The healthy mitral valve model yielded biomechanical predictions in terms of valve closure dynamics, leaflet stresses and papillary muscle and chordae forces comparable to previous computational and experimental studies. Mitral valve function was compromised in geometries representing disease, expressed by the presence of regurgitating areas, elevated stress on the leaflets and unbalanced subvalvular apparatus forces. This showcases the flexibility of the toolbox concerning the generation of a range of mitral valve models with varying geometric definitions and material properties and the evaluation of their biomechanics.
| Type: | Article |
|---|---|
| Title: | A geometry-based finite element tool for evaluating mitral valve biomechanics |
| Location: | England |
| DOI: | 10.1016/j.medengphy.2023.104067 |
| Publisher version: | https://doi.org/10.1016/j.medengphy.2023.104067 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Biomechanics, finite element analysis, mitral valve, morphometry; parametric model |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10186531 |
Archive Staff Only
 |
View Item |
