Ferreira, Josie Liane;
Heincke, Dorothee;
Wichers, Jan Stephan;
Liffner, Benjamin;
Wilson, Danny W;
Gilberger, Tim-Wolf;
(2021)
The Dynamic Roles of the Inner Membrane Complex in the Multiple Stages of the Malaria Parasite.
Frontiers in Cellular and Infection Microbiology
, 10
, Article 611801. 10.3389/fcimb.2020.611801.
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Abstract
Apicomplexan parasites, such as human malaria parasites, have complex lifecycles encompassing multiple and diverse environmental niches. Invading, replicating, and escaping from different cell types, along with exploiting each intracellular niche, necessitate large and dynamic changes in parasite morphology and cellular architecture. The inner membrane complex (IMC) is a unique structural element that is intricately involved with these distinct morphological changes. The IMC is a double membrane organelle that forms de novo and is located beneath the plasma membrane of these single-celled organisms. In Plasmodium spp. parasites it has three major purposes: it confers stability and shape to the cell, functions as an important scaffolding compartment during the formation of daughter cells, and plays a major role in motility and invasion. Recent years have revealed greater insights into the architecture, protein composition and function of the IMC. Here, we discuss the multiple roles of the IMC in each parasite lifecycle stage as well as insights into its sub-compartmentalization, biogenesis, disassembly and regulation during stage conversion of P. falciparum.
| Type: | Article |
|---|---|
| Title: | The Dynamic Roles of the Inner Membrane Complex in the Multiple Stages of the Malaria Parasite |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fcimb.2020.611801 |
| Publisher version: | http://dx.doi.org/10.3389/fcimb.2020.611801 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Alveolata, Apicomplexa, Plasmodium, inner membrane complex, malaria, membrane dynamics, Animals, Cell Membrane, Humans, Malaria, Parasites, Plasmodium, Plasmodium falciparum, Protozoan Proteins |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10185835 |
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