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Fission yeast obeys a linear size law under nutrient titration

Bertaux, François; Kleijn, Istvan T; Marguerat, Samuel; Shahrezaei, Vahid; (2023) Fission yeast obeys a linear size law under nutrient titration. microPublication Biology , 2023 10.17912/micropub.biology.000833. Green open access

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Abstract

Steady-state cell size and geometry depend on growth conditions. Here, we use an experimental setup based on continuous culture and single-cell imaging to study how cell volume, length, width and surface-to-volume ratio vary across a range of growth conditions including nitrogen and carbon titration, the choice of nitrogen source, and translation inhibition. Overall, we find cell geometry is not fully determined by growth rate and depends on the specific mode of growth rate modulation. However, under nitrogen and carbon titrations, we observe that the cell volume and the growth rate follow the same linear scaling.

Type: Article
Title: Fission yeast obeys a linear size law under nutrient titration
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.17912/micropub.biology.000833
Publisher version: http://doi.org/10.17912/micropub.biology.000833
Language: English
Additional information: © 2023 by the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/10185808
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