Shoop‐Worrall, Stephanie JW;
Macintyre, Vanessa G;
Ciurtin, Coziana;
Cleary, Gavin;
McErlane, Flora;
Wedderburn, Lucy R;
Hyrich, Kimme L;
(2024)
Overlap of ILAR and Preliminary PRINTO Classification Criteria for Non-Systemic Juvenile Idiopathic Arthritis in an Established UK Cohort: Results from the Childhood Arthritis Prospective Study.
Arthritis Care & Research
10.1002/acr.25296.
(In press).
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Overlap of ILAR and Preliminary PRINTO Classification Criteria.pdf - Accepted Version Access restricted to UCL open access staff until 17 July 2024. Download (1MB) |
Abstract
Objectives: To assess the degree of overlap between existing International League of Associations for Rheumatology (ILAR) and preliminary Pediatric Rheumatology International Trials Organization (PRINTO) classification criteria for JIA. / Methods: Participants from the Childhood Arthritis Prospective Study, a multicentre UK JIA inception cohort, were classified using the PRINTO and ILAR classification criteria into distinct categories. Systemic JIA was excluded as several classification items were not collected in this cohort. Adaptations to PRINTO criteria were required to apply to a UK healthcare setting, including limiting the number of blood biomarker tests required. The overlap between categories under the two systems was determined and any differences in characteristics between groups described. / Results: A total of 1,223 children and young people with a physician's diagnosis of JIA were included. Using PRINTO criteria, the majority of children had “Other JIA” (69.5%). There was a high degree of overlap (91%) between the PRINTO enthesitis/spondylitis‐ and ILAR enthesitis‐related JIA categories. The PRINTO RF‐positive category was composed of 48% ILAR RF‐positive polyarthritis and 52% undifferentiated JIA. The early‐onset ANA‐positive PRINTO category was largely composed of ILAR oligoarthritis (50%), RF‐negative polyarthritis (24%) and undifferentiated JIA (23%). Few children were unclassified under PRINTO (n=3) and would previously have been classified as enthesitis‐related JIA (n=1) and undifferentiated JIA (n=2) under ILAR. / Conclusion: Under the preliminary PRINTO classification criteria for childhood arthritis, most children are not yet classified into a named category. These data can help support further delineation of the PRINTO criteria to ensure homogenous groups of children can be identified.
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