Seidlitz, Jakob;
Váša, František;
Shinn, Maxwell;
Romero-Garcia, Rafael;
Whitaker, Kirstie J;
Vértes, Petra E;
Reardon, Paul Kirkpatrick;
... Bullmore, Edward T; + view all
(2018)
Morphometric Similarity Networks Detect Microscale Cortical Organisation and Predict Inter-Individual Cognitive Variation.
SSRN: Amsterdam, Netherlands.
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Abstract
Macroscopic cortical networks are important for cognitive function, but it remains challenging to construct anatomically plausible individual structural connectomes from human neuroimaging. We introduce a new technique for cortical network mapping, based on inter-regional similarity of multiple morphometric parameters measured using multimodal MRI. In three cohorts (two human, one macaque), we find that the resulting morphometric similarity networks (MSNs) have a complex topological organization comprising modules and high-degree hubs. Human MSN modules recapitulate known cortical cytoarchitectonic divisions, and greater inter-regional morphometric similarity was associated with stronger inter-regional co-expression of genes enriched for neuronal terms. Comparing macaque MSNs to tract-tracing data confirmed that morphometric similarity was related to axonal connectivity. Finally, variation in the degree of human MSN nodes accounted for about 40% of between-subject variability in IQ. Morphometric similarity mapping provides a novel, robust and biologically plausible approach to understanding how human cortical networks underpin individual differences in psychological functions.
| Type: | Working / discussion paper |
|---|---|
| Title: | Morphometric Similarity Networks Detect Microscale Cortical Organisation and Predict Inter-Individual Cognitive Variation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2139/ssrn.3155515 |
| Publisher version: | https://dx.doi.org/10.2139/ssrn.3155515 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | brain networks, MRI, IQ, cytoarchitecture, gene expression, cross-species, macaque, morphometry |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10179632 |
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