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Generative replay underlies compositional inference in the hippocampal-prefrontal circuit

Schwartenbeck, Philipp; Baram, Alon; Liu, Yunzhe; Mark, Shirley; Muller, Timothy; Dolan, Raymond; Botvinick, Matthew; ... Behrens, Timothy; + view all (2023) Generative replay underlies compositional inference in the hippocampal-prefrontal circuit. Cell 10.1016/j.cell.2023.09.004. (In press). Green open access

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Abstract

Human reasoning depends on reusing pieces of information by putting them together in new ways. However, very little is known about how compositional computation is implemented in the brain. Here, we ask participants to solve a series of problems that each require constructing a whole from a set of elements. With fMRI, we find that representations of novel constructed objects in the frontal cortex and hippocampus are relational and compositional. With MEG, we find that replay assembles elements into compounds, with each replay sequence constituting a hypothesis about a possible configuration of elements. The content of sequences evolves as participants solve each puzzle, progressing from predictable to uncertain elements and gradually converging on the correct configuration. Together, these results suggest a computational bridge between apparently distinct functions of hippocampal-prefrontal circuitry and a role for generative replay in compositional inference and hypothesis testing.

Type: Article
Title: Generative replay underlies compositional inference in the hippocampal-prefrontal circuit
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2023.09.004
Publisher version: https://doi.org/10.1016/j.cell.2023.09.004
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Neural replay; prefrontal-hippocampal circuit; compositional inference; cognitive maps; flexible reasoning
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10179099
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