Pedrigi, Ryan M;
Mehta, Vikram V;
Bovens, Sandra M;
Mohri, Zahra;
Poulsen, Christian Bo;
Gsell, Willy;
Tremoleda, Jordi L;
... Krams, Rob; + view all
(2016)
Influence of shear stress magnitude and direction on atherosclerotic plaque composition.
Royal Society Open Science
, 3
(10)
, Article 160588. 10.1098/rsos.160588.
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Abstract
The precise flow characteristics that promote different atherosclerotic plaque types remain unclear. We previously developed a blood flow-modifying cuff for ApoE−/− mice that induces the development of advanced plaques with vulnerable and stable features upstream and downstream of the cuff, respectively. Herein, we sought to test the hypothesis that changes in flow magnitude promote formation of the upstream (vulnerable) plaque, whereas altered flow direction is important for development of the downstream (stable) plaque. We instrumented ApoE−/− mice (n=7) with a cuff around the left carotid artery and imaged them with micro-CT (39.6 μm resolution) eight to nine weeks after cuff placement. Computational fluid dynamics was then performed to compute six metrics that describe different aspects of atherogenic flow in terms of wall shear stress magnitude and/or direction. In a subset of four imaged animals, we performed histology to confirm the presence of advanced plaques and measure plaque length in each segment. Relative to the control artery, the region upstream of the cuff exhibited changes in shear stress magnitude only (p<0.05), whereas the region downstream of the cuff exhibited changes in shear stress magnitude and direction (p<0.05). These data suggest
| Type: | Article |
|---|---|
| Title: | Influence of shear stress magnitude and direction on atherosclerotic plaque composition |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsos.160588 |
| Publisher version: | https://doi.org/10.1098/rsos.160588 |
| Language: | English |
| Additional information: | © 2016 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| Keywords: | Atherosclerosis, biomechanics, haemodynamics, endothelial cell, micro-computed tomography, thin cap fibroatheroma |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10178958 |
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