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High-Definition Blood Flow Imaging Improves Quantification of LV volumes and Ejection Fraction

Gama, Francisco; Custódio, Pedro; Tsagkridi, Aliki; Moon, James; Lloyd, Guy; Treibel, Thomas A; Bhattacharyya, Sanjeev; (2023) High-Definition Blood Flow Imaging Improves Quantification of LV volumes and Ejection Fraction. European Heart Journal - Cardiovascular Imaging , Article jead245. 10.1093/ehjci/jead245. (In press).

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Abstract

AIMS: The accuracy and reproducibility of echocardiography to quantify left ventricular ejection (LVEF) is limited due to image quality. High-definition blood flow imaging is a new technique which improves cavity delineation without the need for medication or intravenous access. We sought to examine the impact of high-definition blood flow imaging on accuracy and reproducibility of LV systolic function assessment. METHODS & RESULTS: Prospective observational study of consecutive patients undergoing two dimensional (2D) and three dimensional (3D) echocardiography (TTE), high-definition blood flow imaging and cardiac magnetic resonance imaging (CMR) within 1 hour of each other. Left ventricular systolic function characterised by left ventricular systolic volumes (LVESV) and diastolic volumes (LVEDV) and LVEF were measured. Seventy-six patients were included. Correlation of 2D TTE with CMR was modest (r = 0.68) with a worse correlation in patients with 3 or more segments not visualised (r = 0.58). High-definition blood flow imaging was feasible in all patients and the correlation of LVEF with CMR was excellent (r = 0.88). The difference between 2D, High-Definition Blood Flow and 3D TTE compared to CMR were 5 ± 9%, 2 ± 5% and 1 ± 3% respectively. The proportion of patients where the grade of LV function was correctly classified improved from 72.3% using 2D TTE to 92.8% using high-definition blood flow imaging. 3D TTE also had excellent correlation with CMR (r = 0.97) however was only feasible in 72.4% of patients. CONCLUSION: High-definition blood flow imaging is highly feasible and significantly improves the diagnostic accuracy and grading of LV function compared to 2D echocardiography.

Type: Article
Title: High-Definition Blood Flow Imaging Improves Quantification of LV volumes and Ejection Fraction
Location: England
DOI: 10.1093/ehjci/jead245
Publisher version: https://doi.org/10.1093/ehjci/jead245
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cardiac Magnetic Resonance, Contrast, Echocardiography, High-Definition Blood Flow, Left Ventricle Ejection Fraction, Three-Dimensional
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10178181
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