Gama, Francisco;
Custódio, Pedro;
Tsagkridi, Aliki;
Moon, James;
Lloyd, Guy;
Treibel, Thomas A;
Bhattacharyya, Sanjeev;
(2023)
High-Definition Blood Flow Imaging Improves Quantification of LV volumes and Ejection Fraction.
European Heart Journal - Cardiovascular Imaging
, Article jead245. 10.1093/ehjci/jead245.
(In press).
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Abstract
AIMS: The accuracy and reproducibility of echocardiography to quantify left ventricular ejection (LVEF) is limited due to image quality. High-definition blood flow imaging is a new technique which improves cavity delineation without the need for medication or intravenous access. We sought to examine the impact of high-definition blood flow imaging on accuracy and reproducibility of LV systolic function assessment. METHODS & RESULTS: Prospective observational study of consecutive patients undergoing two dimensional (2D) and three dimensional (3D) echocardiography (TTE), high-definition blood flow imaging and cardiac magnetic resonance imaging (CMR) within 1 hour of each other. Left ventricular systolic function characterised by left ventricular systolic volumes (LVESV) and diastolic volumes (LVEDV) and LVEF were measured. Seventy-six patients were included. Correlation of 2D TTE with CMR was modest (r = 0.68) with a worse correlation in patients with 3 or more segments not visualised (r = 0.58). High-definition blood flow imaging was feasible in all patients and the correlation of LVEF with CMR was excellent (r = 0.88). The difference between 2D, High-Definition Blood Flow and 3D TTE compared to CMR were 5 ± 9%, 2 ± 5% and 1 ± 3% respectively. The proportion of patients where the grade of LV function was correctly classified improved from 72.3% using 2D TTE to 92.8% using high-definition blood flow imaging. 3D TTE also had excellent correlation with CMR (r = 0.97) however was only feasible in 72.4% of patients. CONCLUSION: High-definition blood flow imaging is highly feasible and significantly improves the diagnostic accuracy and grading of LV function compared to 2D echocardiography.
| Type: | Article |
|---|---|
| Title: | High-Definition Blood Flow Imaging Improves Quantification of LV volumes and Ejection Fraction |
| Location: | England |
| DOI: | 10.1093/ehjci/jead245 |
| Publisher version: | https://doi.org/10.1093/ehjci/jead245 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cardiac Magnetic Resonance, Contrast, Echocardiography, High-Definition Blood Flow, Left Ventricle Ejection Fraction, Three-Dimensional |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10178181 |
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