Maier, JA;
Andrés, V;
Castiglioni, S;
Giudici, A;
Lau, ES;
Nemcsik, J;
Seta, F;
... Hamburg, NM; + view all
(2023)
Aging and Vascular Disease: A Multidisciplinary Overview.
Journal of Clinical Medicine
, 12
(17)
, Article 5512. 10.3390/jcm12175512.
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Abstract
Vascular aging, i.e., the deterioration of the structure and function of the arteries over the life course, predicts cardiovascular events and mortality. Vascular degeneration can be recognized before becoming clinically symptomatic; therefore, its assessment allows the early identification of individuals at risk. This opens the possibility of minimizing disease progression. To review these issues, a search was completed using PubMed, MEDLINE, and Google Scholar from 2000 to date. As a network of clinicians and scientists involved in vascular medicine, we here describe the structural and functional age-dependent alterations of the arteries, the clinical tools for an early diagnosis of vascular aging, and the cellular and molecular events implicated. It emerges that more studies are necessary to identify the best strategy to quantify vascular aging, and to design proper physical activity programs, nutritional and pharmacological strategies, as well as social interventions to prevent, delay, and eventually revert the disease.
| Type: | Article |
|---|---|
| Title: | Aging and Vascular Disease: A Multidisciplinary Overview |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/jcm12175512 |
| Publisher version: | https://doi.org/10.3390/jcm12175512 |
| Language: | English |
| Additional information: | © 2023 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | aging; arteries; cardiovascular diseases |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10177035 |
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