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Intravitreal implants manufactured by supercritical foaming for treating retinal diseases

Bendicho-Lavilla, Carlos; Seoane-Viaño, Iria; Santos-Rosales, Víctor; Díaz-Tomé, Victoria; Carracedo-Pérez, María; Luzardo-Álvarez, Asteria M; García-González, Carlos A; (2023) Intravitreal implants manufactured by supercritical foaming for treating retinal diseases. Journal of Controlled Release , 362 pp. 342-355. 10.1016/j.jconrel.2023.08.047. Green open access

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Abstract

Chronic retinal diseases, such as age-related macular degeneration (AMD), are a major cause of global visual impairment. However, current treatment methods involving repetitive intravitreal injections pose financial and health burdens for patients. The development of controlled drug release systems, particularly for biological drugs, is still an unmet need in prolonging drug release within the vitreous chamber. To address this, green supercritical carbon dioxide (scCO2) foaming technology was employed to manufacture porous poly(lactic-co-glycolic acid) (PLGA)-based intravitreal implants loaded with dexamethasone. The desired implant dimensions were achieved through 3D printing of customised moulds. By varying the depressurisation rates during the foaming process, implants with different porosities and dexamethasone release rates were successfully obtained. These implants demonstrated controlled drug release for up to four months, surpassing the performance of previously developed implants. In view of the positive results obtained, a pilot study was conducted using the monoclonal antibody bevacizumab to explore the feasibility of this technology for preparing intraocular implants loaded with biologic drug molecules. Overall, this study presents a greener and more sustainable alternative to conventional implant manufacturing techniques, particularly suited for drugs that are susceptible to degradation under harsh conditions.

Type: Article
Title: Intravitreal implants manufactured by supercritical foaming for treating retinal diseases
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jconrel.2023.08.047
Publisher version: https://doi.org/10.1016/j.jconrel.2023.08.047
Language: English
Additional information: Copyright © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Keywords: Supercritical foaming utilizing CO2; PLGA intravitreal implants; Dexamethasone; Monoclonal antibodies; Age-related macular degeneration (ADM); Three (3D)-dimensional printing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10176555
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