Altmann, Daniel M;
Reynolds, Catherine J;
Joy, George;
Otter, Ashley D;
Gibbons, Joseph M;
Pade, Corinna;
Swadling, Leo;
... Boyton, Rosemary J; + view all
(2023)
Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity.
Nature Communications
, 14
(1)
, Article 5139. 10.1038/s41467-023-40460-1.
Preview |
PDF
s41467-023-40460-1.pdf - Published Version Download (1MB) | Preview |
Abstract
Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in Long Covid is whether there is a contributory role of abnormal immunity during acute infection. It has been proposed that Long Covid is a consequence of either an excessive or inadequate initial immune response. Here, we analyze SARS-CoV-2 humoral and cellular immunity in 86 healthcare workers with laboratory confirmed mild or asymptomatic SARS-CoV-2 infection during the first wave. Symptom questionnaires allow stratification into those with persistent symptoms and those without for comparison. During the period up to 18-weeks post-infection, we observe no difference in antibody responses to spike RBD or nucleoprotein, virus neutralization, or T cell responses. Also, there is no difference in the profile of antibody waning. Analysis at 1-year, after two vaccine doses, comparing those with persistent symptoms to those without, again shows similar SARS-CoV-2 immunity. Thus, quantitative differences in these measured parameters of SARS-CoV-2 adaptive immunity following mild or asymptomatic acute infection are unlikely to have contributed to Long Covid causality. ClinicalTrials.gov (NCT04318314).
Type: | Article |
---|---|
Title: | Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1038/s41467-023-40460-1 |
Publisher version: | https://doi.org/10.1038/s41467-023-40460-1 |
Language: | English |
Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
Keywords: | Humans, Antibodies, Viral, Asymptomatic Infections, COVID-19, Post-Acute COVID-19 Syndrome, SARS-CoV-2, T-Lymphocytes |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science |
URI: | https://discovery.ucl.ac.uk/id/eprint/10175993 |
Archive Staff Only
View Item |