Burgess, S;
Davey Smith, G;
Davies, NM;
Dudbridge, F;
Gill, D;
Glymour, MM;
Hartwig, FP;
... Theodoratou, E; + view all
(2020)
Guidelines for performing Mendelian randomization investigations [version 2; peer review: 2 approved].
Wellcome Open Research
, 4
, Article 186. 10.12688/wellcomeopenres.15555.2.
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Abstract
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.
| Type: | Article |
|---|---|
| Title: | Guidelines for performing Mendelian randomization investigations [version 2; peer review: 2 approved] |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.12688/wellcomeopenres.15555.2 |
| Publisher version: | https://doi.org/10.12688/wellcomeopenres.15555.2 |
| Language: | English |
| Additional information: | Copyright: © 2023 Burgess S et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Mendelian randomization, causal inference, genetic epidemiology, guidelines |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry > Epidemiology and Applied Clinical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10174993 |
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