UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

International Validation of the Erasmus Guillain–Barré Syndrome Respiratory Insufficiency Score

Doets, Alex Y; Walgaard, Christa; Lingsma, Hester F; Islam, Badrul; Papri, Nowshin; Yamagishi, Yuko; Kusunoki, Susumu; ... Jacobs, Bart C; + view all (2022) International Validation of the Erasmus Guillain–Barré Syndrome Respiratory Insufficiency Score. Annals of Neurology , 91 (4) pp. 521-531. 10.1002/ana.26312. Green open access

[thumbnail of Doets-2022-International Validation of the Era.pdf]
Preview
Text
Doets-2022-International Validation of the Era.pdf - Other

Download (620kB) | Preview

Abstract

OBJECTIVE: This study aimed to validate the Erasmus Guillain–Barré Syndrome Respiratory Insufficiency Score in the International Guillain–Barré Syndrome Outcome Study cohort, and to improve its performance and region-specificity. METHODS: We examined data from the first 1,500 included patients, aged ≥6 years and not ventilated prior to study entry. Patients with a clinical variant or mild symptoms were also included. Outcome was mechanical ventilation within the first week from study entry. Model performance was assessed regarding the discriminative ability (area under the receiver operating characteristic curve) and the calibration (observed vs predicted probability of mechanical ventilation), in the full cohort and in Europe/North America and Asia separately. We recalibrated the model to improve its performance and region-specificity. RESULTS: In the group of 1,023 eligible patients (Europe/North America n = 842, Asia n = 104, other n = 77), 104 (10%) required mechanical ventilation within the first week from study entry. Area under the curve values were ≥0.80 for all validation subgroups. Mean observed proportions of mechanical ventilation were lower than predicted risks: full cohort 10% versus 21%, Europe/North America 9% versus 21%, and Asia 17% versus 23%. After recalibration, predicted risks for the full cohort and Europe/North America corresponded to observed proportions. INTERPRETATION: This prospective, international cohort study validated the Erasmus Guillain–Barré Syndrome Respiratory Insufficiency Score, and showed that the model can be used in the full spectrum of Guillain–Barré syndrome patients. In addition, a more accurate, region-specific version of the model was developed for patients from Europe/North America. ANN NEUROL 2022;91:521–531

Type: Article
Title: International Validation of the Erasmus Guillain–Barré Syndrome Respiratory Insufficiency Score
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ana.26312
Publisher version: https://doi.org/10.1002/ana.26312
Language: English
Additional information: © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10174267
Downloads since deposit
4Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item