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The tumour ecology of quiescence: Niches across scales of complexity

Castillo, Simon P; Galvez-Cancino, Felipe; Liu, Jiali; Pollard, Steven M; Quezada, Sergio A; Yuan, Yinyin; (2023) The tumour ecology of quiescence: Niches across scales of complexity. Seminars in Cancer Biology , 92 pp. 139-149. 10.1016/j.semcancer.2023.04.004. Green open access

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Abstract

Quiescence is a state of cell cycle arrest, allowing cancer cells to evade anti-proliferative cancer therapies. Quiescent cancer stem cells are thought to be responsible for treatment resistance in glioblastoma, an aggressive brain cancer with poor patient outcomes. However, the regulation of quiescence in glioblastoma cells involves a myriad of intrinsic and extrinsic mechanisms that are not fully understood. In this review, we synthesise the literature on quiescence regulatory mechanisms in the context of glioblastoma and propose an ecological perspective to stemness-like phenotypes anchored to the contemporary concepts of niche theory. From this perspective, the cell cycle regulation is multiscale and multidimensional, where the niche dimensions extend to extrinsic variables in the tumour microenvironment that shape cell fate. Within this conceptual framework and powered by ecological niche modelling, the discovery of microenvironmental variables related to hypoxia and mechanosignalling that modulate proliferative plasticity and intratumor immune activity may open new avenues for therapeutic targeting of emerging biological vulnerabilities in glioblastoma.

Type: Article
Title: The tumour ecology of quiescence: Niches across scales of complexity
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.semcancer.2023.04.004
Publisher version: https://doi.org/10.1016/j.semcancer.2023.04.004
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Glioblastoma, Tumour ecology, Intratumor heterogeneity, Quiescence, Cell cycle, Niche, CANCER STEM-CELLS, EXTRACELLULAR-MATRIX, GLIOBLASTOMA REVEALS, GROWTH-FACTOR, IFN-GAMMA, T-CELLS, EVOLUTION, DORMANCY, POPULATION, NECROSIS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10173593
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