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Vaccination in liver diseases and liver Transplantation: Recommendations, implications and opportunities in the post-covid era

Ballester, Maria Pilar; Jalan, Rajiv; Mehta, Gautam; (2023) Vaccination in liver diseases and liver Transplantation: Recommendations, implications and opportunities in the post-covid era. JHEP Reports , 5 (8) , Article 100776. 10.1016/j.jhepr.2023.100776. (In press). Green open access

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Abstract

The interest in vaccination efficacy and toxicity has surged following the Covid-19 pandemic. Immune responses to several vaccines have been shown to be suboptimal in patients with chronic liver disease (CLD) or post-liver transplant (LT), as a consequence of cirrhosis-associated immune dysfunction (CAID) or post-LT immunosuppression respectively. Accordingly, vaccine-preventable infections may be more common or severe than in the general population. The Covid-19 pandemic has greatly accelerated research and development into vaccination technology and platforms, which will have spillover benefits for liver patients. The aims of this review are: (i) to discuss the impact of vaccine-preventable infections on CLD and post-LT patients, (ii) to appraise current evidence supporting vaccination strategies, and (iii) to provide some insight into recent developments relevant for liver patients.

Type: Article
Title: Vaccination in liver diseases and liver Transplantation: Recommendations, implications and opportunities in the post-covid era
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jhepr.2023.100776
Publisher version: https://doi.org/10.1016/j.jhepr.2023.100776
Language: English
Additional information: © 2023 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
Keywords: Cirrhosis, Covid-19, Hepatitis, Liver transplant, Vaccination
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10173307
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