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Cachexia: A systemic consequence of progressive, unresolved disease

Ferrer, M; Anthony, TG; Ayres, JS; Biffi, G; Brown, JC; Caan, BJ; Cespedes Feliciano, EM; ... Janowitz, T; + view all (2023) Cachexia: A systemic consequence of progressive, unresolved disease. Cell , 186 (9) pp. 1824-1845. 10.1016/j.cell.2023.03.028.

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Abstract

Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away from advanced cachexia to the etiology of cachexia may enable discoveries of new therapeutic approaches. Here, we review drivers, mechanisms, organismal predispositions, evidence for multi-organ interaction, model systems, clinical research, trials, and care provision from early onset to late cachexia. Evidence is emerging that distinct inflammatory, metabolic, and neuro-modulatory drivers can initiate processes that ultimately converge on advanced cachexia.

Type: Article
Title: Cachexia: A systemic consequence of progressive, unresolved disease
Location: United States
DOI: 10.1016/j.cell.2023.03.028
Publisher version: https://doi.org/10.1016/j.cell.2023.03.028
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10171790
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