Gidziela, Agnieszka;
Ahmadzadeh, Yasmin II;
Michelini, Giorgia;
Allegrini, Andrea GG;
Agnew-Blais, Jessica;
Lau, Lok Yan;
Duret, Megan;
... Malanchini, Margherita; + view all
(2023)
A meta-analysis of genetic effects associated with neurodevelopmental disorders and co-occurring conditions.
Nature Human Behaviour
, 7
pp. 642-656.
10.1038/s41562-023-01530-y.
(In press).
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Abstract
A systematic understanding of the aetiology of neurodevelopmental disorders (NDDs) and their co-occurrence with other conditions during childhood and adolescence remains incomplete. In the current meta-analysis, we synthesized the literature on (1) the contribution of genetic and environmental factors to NDDs, (2) the genetic and environmental overlap between different NDDs, and (3) the co-occurrence between NDDs and disruptive, impulse control and conduct disorders (DICCs). Searches were conducted across three platforms: Web of Science, Ovid Medline and Ovid Embase. Studies were included only if 75% or more of the sample consisted of children and/or adolescents and the studies had measured the aetiology of NDDs and DICCs using single-generation family designs or genomic methods. Studies that had selected participants on the basis of unrelated diagnoses or injuries were excluded. We performed multilevel, random-effects meta-analyses on 296 independent studies, including over four million (partly overlapping) individuals. We further explored developmental trajectories and the moderating roles of gender, measurement, geography and ancestry. We found all NDDs to be substantially heritable (family-based heritability, 0.66 (s.e. = 0.03); SNP heritability, 0.19 (s.e. = 0.03)). Meta-analytic genetic correlations between NDDs were moderate (grand family-based genetic correlation, 0.36 (s.e. = 0.12); grand SNP-based genetic correlation, 0.39 (s.e. = 0.19)) but differed substantially between pairs of disorders. The genetic overlap between NDDs and DICCs was strong (grand family-based genetic correlation, 0.62 (s.e. = 0.20)). While our work provides evidence to inform and potentially guide clinical and educational diagnostic procedures and practice, it also highlights the imbalance in the research effort that has characterized developmental genetics research.
| Type: | Article |
|---|---|
| Title: | A meta-analysis of genetic effects associated with neurodevelopmental disorders and co-occurring conditions |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41562-023-01530-y |
| Publisher version: | https://doi.org/10.1038/s41562-023-01530-y |
| Language: | English |
| Additional information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Social Sciences, Science & Technology, Life Sciences & Biomedicine, Psychology, Biological, Multidisciplinary Sciences, Neurosciences, Psychology, Experimental, Psychology, Science & Technology - Other Topics, Neurosciences & Neurology, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, DEVELOPMENTAL COORDINATION DISORDER, AUTISM SPECTRUM DISORDERS, ENVIRONMENTAL-INFLUENCES, ADHD, CHILDHOOD, HYPERACTIVITY, ADOLESCENCE, SYMPTOMS, CHILDREN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10169238 |
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