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Oestrogenic Regulation of Mitochondrial Dynamics

Beikoghli Kalkhoran, Siavash; Kararigas, Georgios; (2022) Oestrogenic Regulation of Mitochondrial Dynamics. International Journal of Molecular Sciences , 23 (3) , Article 1118. 10.3390/ijms23031118. Green open access

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Biological sex influences disease development and progression. The steroid hormone 17β-oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation of sex differences. E2 exerts pleiotropic effects in a system-specific manner. Mitochondria are one of the central targets of E2, and their biogenesis and respiration are known to be modulated by E2. More recently, it has become apparent that E2 also regulates mitochondrial fusion-fission dynamics, thereby affecting cellular metabolism. The aim of this article is to discuss the regulatory pathways by which E2 orchestrates the activity of several components of mitochondrial dynamics in the cardiovascular and nervous systems in health and disease. We conclude that E2 regulates mitochondrial dynamics to maintain the mitochondrial network promoting mitochondrial fusion and attenuating mitochondrial fission in both the cardiovascular and nervous systems.

Type: Article
Title: Oestrogenic Regulation of Mitochondrial Dynamics
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/ijms23031118
Publisher version: https://doi.org/10.3390/ijms23031118
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemistry & Molecular Biology, Chemistry, Multidisciplinary, Chemistry, 17 beta-oestradiol, biological sex, cardiovascular, heart-brain axis, neuronal, ISCHEMIA-REPERFUSION INJURY, RECEPTOR-BETA ATTENUATE, SEX-DIFFERENCES, PERMEABILITY TRANSITION, DEPENDENT REGULATION, SKELETAL-MUSCLE, CARDIAC GROWTH, CELL-DEATH, FUSION, HEART
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: https://discovery.ucl.ac.uk/id/eprint/10164893
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