Volz, L;
Collins-Fekete, C-A;
Baer, E;
Brons, S;
Graeff, C;
Johnson, RP;
Runz, A;
... Seco, J; + view all
(2021)
The accuracy of helium ion CT based particle therapy range prediction: an experimental study comparing different particle and x-ray CT modalities.
Physics in Medicine and Biology
, 66
(23)
, Article 235010. 10.1088/1361-6560/ac33ec.
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Abstract
This work provides a quantitative assessment of helium ion CT (HeCT) for particle therapy treatment planning. For the first time, HeCT based range prediction accuracy in a heterogeneous tissue phantom is presented and compared to single-energy x-ray CT (SECT), dual-energy x-ray CT (DECT) and proton CT (pCT). HeCT and pCT scans were acquired using the US pCT collaboration prototype particle CT scanner at the Heidelberg Ion-Beam Therapy Center. SECT and DECT scans were done with a Siemens Somatom Definition Flash and converted to RSP. A Catphan CTP404 module was used to study the RSP accuracy of HeCT. A custom phantom of 20 cm diameter containing several tissue equivalent plastic cubes was used to assess the spatial resolution of HeCT and compare it to DECT. A clinically realistic heterogeneous tissue phantom was constructed using cranial slices from a pig head placed inside a cylindrical phantom ( 150 mm). A proton beam (84.67 mm range) depth-dose measurement was acquired using a stack of GafchromicTM EBT-XD films in a central dosimetry insert in the phantom. CT scans of the phantom were acquired with each modality, and proton depth-dose estimates were simulated based on the reconstructions. The RSP accuracy of HeCT for the plastic phantom was found to be 0.3 0.1%. The spatial resolution for HeCT of the cube phantom was 5.9 0.4 lp cm-1 for central, and 7.6 0.8 lp cm-1 for peripheral cubes, comparable to DECT spatial resolution (7.7 0.3 lp cm-1 and 7.4 0.2 lp cm-1, respectively). For the pig head, HeCT, SECT, DECT and pCT predicted range accuracy was 0.25%, -1.40%, -0.45% and 0.39%, respectively. In this study, HeCT acquired with a prototype system showed potential for particle therapy treatment planning, offering RSP accuracy, spatial resolution, and range prediction accuracy comparable to that achieved with a commercial DECT scanner. Still, technical improvements of HeCT are needed to enable clinical implementation.
| Type: | Article |
|---|---|
| Title: | The accuracy of helium ion CT based particle therapy range prediction: an experimental study comparing different particle and x-ray CT modalities |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1361-6560/ac33ec |
| Publisher version: | http://dx.doi.org/10.1088/1361-6560/ac33ec |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CALIBRATION, DETECTORS, dual-energy CT, DUAL-ENERGY CT, Engineering, Engineering, Biomedical, helium ions, Life Sciences & Biomedicine, particle CT, particle therapy, PLATFORM, proton ct, PROTON CT, RADIOGRAPHY, Radiology, Nuclear Medicine & Medical Imaging, range accuracy, Science & Technology, SPATIAL-RESOLUTION, STOPPING-POWER, Technology, tissue, TRACKING, UNCERTAINTIES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10164437 |
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